Peer Reviewed Journal
<i>MicroRNA-26b−/−</i> augments atherosclerosis, while mimic-loaded nanoparticles reduce atherogenesis
Authors
Linsey J. F. Peters, Kiril Bidzhekov, Andrea Bonnin-Marquez, Sai Sahana Sundararaman, Rosanna Huchzermeier, Sanne L. Maas, Kathrin Abschlag, Alexander Jans, Cheng Lin, Markus Haberbosch, Yvonne Jansen, Baixue Yu, Judith C. Sluimer, Marion J. Gijbels, Joachim Jankowski, Matthias Bartneck, Erik A.L. Biessen, Christian Weber, Yvonne Döring, Emiel P. C. van der Vorst
Citation
Linsey J. F. Peters, K. (2025). MicroRNA-26b−/− augments atherosclerosis, while mimic-loaded nanoparticles reduce atherogenesis. https://doi.org/10.1093/cvr/cvaf234
Abstract
Overall, our results clearly demonstrate an atheroprotective role of miR-26b by attenuating lesion formation, mainly by suppressing inflammation and stimulating collagen breakdown. Furthermore, the therapeutic potential of miR-26b mimic-loaded LNPs could be proven, opening up new avenues for miRNA-based treatment options in the future.
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