Peer Reviewed Journal

A rapid genome-proteome approach to identify rate-limiting steps in the butyrate production pathway in probiotic Clostridium butyricum, CBM588

Liam Wood, Bunmi B. Omorotionmwan, Adam Blanchard, Adam Dowle, David Tooth, Tom S. Bailey, Ruth Griffin

Liam Wood, B. (2025). A rapid genome-proteome approach to identify rate-limiting steps in the butyrate production pathway in probiotic Clostridium butyricum, CBM588. Anaerobe. https://doi.org/10.1016/j.anaerobe.2025.102940

Our findings pave the way for over-expressing these genes chromosomally to generate a recombinant probiotic with improved butyrate production and potentially enhanced gut health properties.