Peer Reviewed Journal

Sex hormone-binding globulin as a biomarker for metabolic risk in European women with polycystic ovary syndrome

Bo E. van Bree, Denise M. B. van der Heijden, Ron J T van Golde, Martijn C.G.J. Brouwers, Marc E. A. Spaanderman, Olivier Valkenburg

Bo E. van Bree, D. (2025). Sex hormone-binding globulin as a biomarker for metabolic risk in European women with polycystic ovary syndrome. Gynecological Endocrinology. https://doi.org/10.1080/09513590.2025.2500462

SHBG levels <40 nmol/L are indicative for metabolic dysregulation in European women with PCOS. Waist circumference is an important predictor for SHBG, comparable to BMI. Visceral adiposity might play an important role in the expression of SHBG and etiology of PCOS.