Peer Reviewed Journal
Proteolytic neutralization of extracellular histones by neutrophil elastase is enhanced by heparin
Authors
Joram Huckriede, Gwen M Keulen, Marcel C.G. van de Poll, Kanin Wichapong, Chris Reutelingsperger, Gerry A. F. Nicolaes
Citation
Joram Huckriede, G. (2025). Proteolytic neutralization of extracellular histones by neutrophil elastase is enhanced by heparin. Journal of Thrombosis and Haemostasis. https://doi.org/10.1016/j.jtha.2025.03.039
Abstract
NE can proteolyze extracellular histones, resulting in reduced cytotoxicity and inflammation in vitro. Histone proteolysis can be enhanced by the addition of heparins, indicating a potential combinatory treatment of histone-mediated events by heparins and NE in acute inflammatory diseases.
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