Vasoconstriction-inhibiting factor: an endogenous inhibitor of vascular calcification as a calcimimetic of calcium-sensing receptor

Sofía de la Puente-Secades, Dustin Mikolajetz, Nathalie Gayrard, Juliane Hermann, Vera Jankowski, Shruti Bhargava, Amina Meyer, Àngel Argilés, Turgay Saritas, Emiel P. C. van der Vorst, Zhuojun Wu, Heidi Noels, Martin Tepel, Khaleda Alghamdi, Donald T. Ward, Walter Zidek, Michael Wolf, J. Floege, Leon J. Schurgers, Setareh Orth-Alampour, Joachim Jankowski

The elucidation of the underlying mechanism by which the VIF peptide inhibits vascular calcification, as well as the active sequence and the cleavage and degradation enzymes, forms the basis for developing preventive and therapeutic measures to counteract vascular calcification.