Genotype-negative hypertrophic cardiomyopathy: Exploring the role of cardiovascular risk factors in disease expression

Stephan A C Schoonvelde, Edgar E. Nollet, Peter-Paul Zwetsloot, Christian Knackstedt, Tjeerd Germans, Alexander Hirsch, Arend F. L. Schinkel, Marjon A. van Slegtenhorst, Judith M.A. Verhagen, Rudolf A. de Boer, Jolanda van der Velden, Michelle Michels

CVRF, particularly hypertension, are more prevalent in G- patients independent of age, suggesting that cardiovascular health may contribute to HCM disease development. Male-female differences suggest female-specific factors affecting the development of HCM in women. Recognizing G- HCM as a distinct clinical entity may have important implications for patient management, and a more comprehensive understanding of its aetiology may aid in tailoring future therapies.