Peer Reviewed Journal

An interpretable ensemble model combining handcrafted radiomics and deep learning for predicting the overall survival of hepatocellular carcinoma patients after stereotactic body radiation therapy

Yi Chen, Dominique Pasquier, Damon Verstappen, Henry C. Woodruff, Philippe Lambin

Yi Chen, D. (2025). An interpretable ensemble model combining handcrafted radiomics and deep learning for predicting the overall survival of hepatocellular carcinoma patients after stereotactic body radiation therapy. Journal of Cancer Research and Clinical Oncology. https://doi.org/10.1007/s00432-025-06119-8

The ensemble model represents a significant advancement, providing a comprehensive tool for predicting survival outcomes in HCC patients undergoing SBRT. The inclusion of interpretability methods such as Grad-CAM enhances transparency and understanding of these complex predictive models.