Factors influencing locoregional recurrence rates in locally advanced rectal cancer after total neoadjuvant treatment <i>versus</i> chemoradiotherapy in the RAPIDO trial

Ilaria Prata, Max D. Tanaka, Bengt Glimelius, Iris D. Nagtegaal, Regina G. H. Beets‐Tan, Lennart K. Blomqvist, Alice M. Couwenberg, Boudewijn van Etten, Geke A.P. Hospers, Elma Meershoek‐Klein Kranenbarg, Koen Peeters, Hein Putter, Annet G.H. Roodvoets, Cornelis J.�H. van de Velde, Per J. Nilsson, Corrie A.M. Marijnen

The difference in LRR between TNT and CRT mainly occurred in patients treated with sphincter-preserving surgery. Baseline information on the original tumour bed should be considered when determining the surgical approach after total neoadjuvant treatment.