Changing definitions of disease: Transformations in the diagnostic criteria for Alzheimer's disease

Lennart H. van der Molen, Marianne Boenink, Harro van Lente, Edo Richard

Early diagnosis and incorporating scientific insights are recurring aims. The aims of new criteria are often not clearly articulated or ambiguous. The number of requirements for an AD diagnosis decreases over time. Consecutive criteria for research and clinical use did not result in clear terminology. The AD definition is increasingly narrowed to amyloid β and tau.