Intestinal blood vessel-associated macrophages and gut-vascular barrier dysfunction in cirrhosis

Lena Smets, Maria Francesca Viola, Markus Boesch, Jana Raman, Lukas Van Melkebeke, Max Nobis, Emilio Flint, Nika Pajk, Paola Brescia, Alessandra Silvestri, Rita Feio‐Azevedo, Elodie Modave, Lander De Herdt, Annalisa Sanga, Oltin T. Pop, Olivier Govaere, Jef Verbeek, Alexandre Denadai‐Souza, David Cassiman, Niels Vandamme, Bram Boeckx, Diether Lambrechts, María Rescigno, Christine Bernsmeier, Elizabeth A. V. Jones, Jan G. Hengstler, Ahmed Ghallab, Colinda L. G. J. Scheele, Frederik Nevens, Hannelie Korf, Guy E. Boeckxstaens, Van der Merwe

This study emphasises the critical role of intestinal macrophages in preventing the dissemination of luminal bacteria and highlights the multifaceted breakdown of the intestinal barrier in cirrhosis and the importance of the gut-vascular barrier.