Diagnostic accuracy of CT for identifying high-risk colon cancer: a systematic review and meta-analysis

Jona Shkurti, Kim van den Berg, Renaud Tissier, Stevie van der Mierden, Max J. Lahaye, Regina G. H. Beets‐Tan, Joost Nederend

Question Accurate CT staging is crucial for guiding neoadjuvant therapy in colon cancer, but its ability to distinguish high-risk from low-risk cases remains uncertain. Findings CT showed high sensitivity for distinguishing pT3-T4 tumors but only moderate sensitivity for pT3cd-T4, nodal involvement, and extramural venous invasion. Clinical relevance This systematic review critically evaluates CT diagnostic accuracy in colon cancer staging, revealing its strengths and limitations. The findings highlight the need for optimized imaging protocols and complementary tools to enhance risk stratification and guide clinical decisions.