Mepolizumab versus benralizumab for eosinophilic granulomatosis with polyangiitis (EGPA): A European real-life retrospective comparative study

Irene Mattioli, Maria Letizia Urban, Roberto Padoan, Aladdin J Mohammad, Carlo Salvarani, Chiara Baldini, Alvise Berti, Paolo Cameli, Marco Caminati, P. Cathébras, Fulvia Chieco Bianchi, Francesco Cinetto, Jan Willem Cohen Tervaert, Angelo Coppola, Giulia Costanzo, Vincent Cottin, Claudia Crimi, Stefano Del Giacco, Charlene Desaintjean, Allyson Egan, Georgina Espígol‐Frigolé, Marco Folci, Marco Fornaro, Franco Franceschini, Marcello Govoni, Matthieu Groh, Gabriella Guarnieri, Bernhard Hellmich, Florenzo Iannone, Rachel Jones, Anna Kernder, Alberto Lo Gullo, Carlo Lombardi, Giuseppe Lopalco, Laura Losappio, Maria Rita Marchi, Carlos Martínez‐Rivera, Chiara Marvisi, Matteo Maule, Laura Moi, Sara Monti, Frank Moosig, Gianluca Moroncini, Simone Negrini, Thomas Neumann, Santi Nolasco, Pavel Novikov, Dario Roccatello, Maxime Samson, Jan Walter Schroeder, Benjamin Seeliger, Renato Alberto Sinico, Roser Solans, Colas Tchérakian, Paola Toniati, Elena Treppo, Giorgio Trivioli, Angelo Vacca, David Jayne, Alessandra Bettiol, Augusto Vaglio, Giacomo Emmi, Giacomo Bagni, Edoardo Biancalana, Philippe Bonniaud, Roberto Bortolotti, Linda Borgonovo, Luisa Brussino, Raffaele Campisi, Lorenzo Carriera, Maria C. Cid, Emanuele Chiara, Laura Coladonato, Leda D'Amico, Paolo Delvino, Fabio Fischetti, Michela Gasparotto, Luca Iorio, Claudia Feder, Andrea G. Ledda, Mariapaola Lisi, Danilo Malandrino, Beatrice Maranini, Sergey Moiseev, Silvia Noviello, Miki Palmerini, Tommaso Pianigiani, Beatrice Piazza, Mario Piga, Luca Quartuccio, Jens Rathmann, Francesca Regola, Caterina Ricordi, Riccardo Scarpa, Savino Sciascia, Elena Silvestri, Paola Tomietto, Barbara Trezzi

Mepolizumab and benralizumab showed comparable overall effectiveness and safety in EGPA. However, benralizumab achieved a higher CR rate at T12, and a deeper peripheral eosinophil reduction.