Depressive Symptoms and Amyloid Pathology

Wietse Wiels, Julie Elisabeth Oomens, Sebastiaan Engelborghs, Chris Baeken, Christine A. F. Von Arnim, Merçé Boada, Mira Didic, Bruno Dubois, Tormod Fladby, Wiesje M. van der Flier, Giovanni B. Frisoni, Lutz Fröhlich, Kiran Dip Gill, Timo Grimmer, Helmut Hildebrandt, Jakub Hort, Yoshiaki Itoh, Takeshi Iwatsubo, Aleksandra Klimkowicz‐Mrowiec, Dong Young Lee, Alberto Lleó, Pablo Martínez‐Lage, Alexandre de Mendonça, Philipp T. Meyer, Elisabeth Kapaki, Piero Parchi, Matteo Pardini, Lucilla Parnetti, Julius Popp, Lorena Rami, Eric M. Reiman, Juha O. Rinne, Karen M. Rodrigue, Pascual Sánchez‐Juan, Isabel Santana, Marie Sarazin, Nikolaos Scarmeas, Ingmar Skoog, Peter J. Snyder, Reisa A. Sperling, Sylvia Villeneuve, Anders Wallin, Jens Wiltfang, Henrik Zetterberg, Rik Ossenkoppele, Frans R.J. Verhey, Stephanie J. B. Vos, Pieter Jelle Visser, Willemijn J. Jansen, Amyloid Biomarker Study group, Daniel Alcolea, Daniele Altomare, Simone Baiardi, Inês Baldeiras, Randall J. Bateman, Kaj Blennow, Michel Bottlaender, Anouk den Braber, Mark A. van Buchem, Min Soo Byun, Jiří Cerman, Kewei Chen, Elena Chipi, Gregory S. Day, Alexander Drzezga, Marie Eckerström, Laura L. Ekblad, Stéphane Epelbaum, Stefan Förster, Juan Fortea, Yvonne Freund‐Levi, Lars Frings, Éric Guedj, Lucrezia Hausner, Sabine Hellwig, Edward D. Huey, J. Jiménez‐Bonilla, Keith A. Johnson, Arantxa Juaristi, Ramesh Kandimalla, George P. Paraskevas, Silke Kern, Bjørn‐Eivind Kirsebom, Johannes Kornhuber, Julien Lagarde, Susan Landau, Nienke Legdeur, Jorge J. Llibre Guerra, Nancy N. Maserejian, Marta Marquié, Shinobu Minatani, Silvia Morbelli, Barbara Mroczko, Eva Ntanasi, Catarina R. Oliveira, Pauline Olivieri, Adelina Orellana, Richard J. Perrin, Oliver Peters, Sudesh Prabhakar

Depressive symptoms were not consistently associated with a higher frequency of amyloid pathology in participants with NC and were associated with a lower likelihood of amyloid pathology in participants with MCI. These findings were not influenced by age, sex, or education level. Mechanisms other than amyloid accumulation may commonly underlie depressive symptoms in late life.